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Proteolysis

  • RESEARCH ARTICLE
    Developing fluorescence sensor probe to capture activated muscle-specific calpain-3 (CAPN3) in living muscle cells
    Koichi Ojima, Shoji Hata, Fumiko Shinkai-Ouchi, Mika Oe, Susumu Muroya, Hiroyuki Sorimachi, Yasuko Ono
    Biology Open 2020 9: bio048975 doi: 10.1242/bio.048975 Published 4 September 2020

    Summary: Our research is the first report of developing sensor probes to detect activated-CAPN3 in cultured skeletal muscle cells.

  • RESEARCH ARTICLE
    Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster
    Jessica R. Blount, Danielle N. Meyer, Camille Akemann, Sean L. Johnson, Katherine Gurdziel, Tracie R. Baker, Sokol V. Todi
    Biology Open 2019 8: bio043372 doi: 10.1242/bio.043372 Published 30 May 2019

    Summary: Our Drosophila studies indicate the lack of a marked, coordinated response towards unanchored poly-ubiquitin in flies, suggesting that untethered ubiquitin chains are not necessarily problematic in intact organisms.

  • RESEARCH ARTICLE
    Influence of a GSK3β phosphorylation site within the proximal C-terminus of Neurofilament-H on neurofilament dynamics
    Rishel Brenna Vohnoutka, Edward F. Boumil, Yuguan Liu, Atsuko Uchida, Harish C. Pant, Thomas B. Shea
    Biology Open 2017 6: 1516-1527; doi: 10.1242/bio.028522

    Summary: We demonstrate that phosphorylation of a critical site regulates neurofilament transport, proteolysis and interaction with other axonal cytoskeletal elements, and present evidence that it does so by altering protein conformation. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • RESEARCH ARTICLE
    Twist1-positive epithelial cells retain adhesive and proliferative capacity throughout dissemination
    Eliah R. Shamir, Kester Coutinho, Dan Georgess, Manfred Auer, Andrew J. Ewald
    Biology Open 2016 5: 1216-1228; doi: 10.1242/bio.019703

    Summary: Twist1+ epithelium retains intercellular junctions and proliferative capacity. During dissemination, Twist1+ cells retain adhesive capacity and exhibit features of both amoeboid and mesenchymal migration modes.

  • RESEARCH ARTICLE
    CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis
    Kanin Salao, Lele Jiang, Hui Li, Vicky W.-W. Tsai, Yasmin Husaini, Paul M. G. Curmi, Louise J. Brown, David A. Brown, Samuel N. Breit
    Biology Open 2016 5: 620-630; doi: 10.1242/bio.018119

    Summary: DC phagosomes from CLIC1−/− mice display impaired acidification and in vivo and in vitro antigen processing and presentation, revealing CLIC1−/− as a potential therapeutic target in reducing the adaptive immune response in autoimmune diseases.

  • RESEARCH ARTICLE
    Complex regulation controls Neurogenin3 proteolysis
    Ryan Roark, Laura Itzhaki, Anna Philpott
    Biology Open 2012 1: 1264-1272; doi: 10.1242/bio.20121750

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