Skeletal muscle
- HSP70 drives myoblast fusion during C2C12 myogenic differentiation
Summary: In C2C12 myoblasts, HSP70 overexpression does not alter proliferation or differentiation but enhances fusion to increase myotube size.
- Effects of inhibiting mTOR with rapamycin on behavior, development, neuromuscular physiology and cardiac function in larval Drosophila
Summary: Inhibiting mTOR by rapamycin delays pupation, reduced body wall contractions and mouth-hook movements while synaptic transmission appeared normal in larval Drosophila.
- Functional domains of the FSHD-associated DUX4 protein
Summary: Aberrant expression of DUX4 underlies facioscapulohumeral muscular dystrophy. This study identified functional domains of DUX4 and demonstrated that multiple pathological changes are related to DUX4-mediated transcriptional activation.
- Molecular regulation of high muscle mass in developing Blonde d'Aquitaine cattle foetuses
Summary: We explored the molecular basis of high muscle mass in Blonde d’Aquitaine cattle, and found that mRNA encoding slow fibres and mitochondrial proteins were downregulated in this breed.
- The expression of Ldh-c in the skeletal muscle of plateau pika (Ochotona curzoniae) enhances adaptation to a hypoxic environment
Summary: The expression of Ldh-c in the skeletal muscle of plateau pika (Ochotona curzoniae) increases anaerobic glycolysis, resulting in enhanced sprint-running capacity and adaptation to a hypoxic environment.
- Training differentially regulates elastin level and proteolysis in skeletal and heart muscles and aorta in healthy rats
Summary: Endurance training increases elastin content in muscles but not in the aorta. The activities of enzymes responsible for ECM remodeling increase only in skeletal muscle. These changes seem to be adaptive.