Stem cell niche
- Notch signaling governs the expression of glypican Dally to define the stem cell niche
Summary: Spatial regulation of a cell surface glycoprotein defines the territory of germline stem cells.
- Cell tracking in vitro reveals that the extracellular matrix glycoprotein Tenascin-C modulates cell cycle length and differentiation in neural stem/progenitor cells of the developing mouse spinal cord
Summary: We have shown, using digital video microscopy based cell lineage tracing, that the glycoprotein of the extracellular matrix tenascin-C modulates growth factor responsiveness and cell cycle length of embryonic spinal cord progenitor cells in vitro.
- Cellular population dynamics control the robustness of the stem cell niche
Summary: Stem cell niche dynamics are very robust to external and physiological perturbations because proliferation and differentiation are naturally balanced and controlled by the reliance on a shared niche environment.