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Tau

  • RESEARCH ARTICLE
    Tau interferes with axonal neurite stabilization and cytoskeletal composition independently of its ability to associate with microtubules
    Edward F. Boumil, Rishel B. Vohnoutka, Sangmook Lee, Thomas B. Shea
    Biology Open 2020 9: bio052530 doi: 10.1242/bio.052530 Published 25 September 2020

    Summary: Tau inhibits axonal transport by blocking kinesin translocation or as kinesin cargo. Tau capable and incapable of microtubule binding inhibited transport equally, indicating inhibition of axonal transport as kinesin cargo.

  • RESEARCH ARTICLE
    Miro, a Rho GTPase genetically interacts with Alzheimer's disease-associated genes (Tau, Aβ42 and Appl) in Drosophila melanogaster
    Komal Panchal, Anand Krishna Tiwari
    Biology Open 2020 9: bio049569 doi: 10.1242/bio.049569 Published 3 September 2020

    Summary: Our study suggests that overexpression of Miro improves the Alzheimer's disease-related pathologies by decreasing the rough eye phenotype, oxidative stress, apoptosis and neurodegeneration and increasing the lifespan, body weight, phototaxis and climbing activity in the Drosophila model of Alzheimer's disease.

  • RESEARCH ARTICLE
    An AMPK-dependent regulatory pathway in tau-mediated toxicity
    Alessia Galasso, Charles S. Cameron, Bruno G. Frenguelli, Kevin G. Moffat
    Biology Open 2017 6: 1434-1444; doi: 10.1242/bio.022863

    Summary: Dissection of the impact of AMPK and autophagy on tau-mediated toxicity by using an in vivo Drosophila tool as readout to perform preliminary drug screening supported by quantitative analyses.

  • RESEARCH ARTICLE
    Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β
    Giulia Povellato, Richard I. Tuxworth, Diane P. Hanger, Guy Tear
    Biology Open 2014 3: 1-11; doi: 10.1242/bio.20136692

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