Transcriptional regulation
- Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis
Summary: Targeted mutations were generated for each of the three gata4/5/6 genes in zebrafish to define functions for individual or combinations of these related transcription factors during cardiogenesis.
- Separate roles for Med12 and Wnt signaling in regulation of oxytocin expression
Summary: Mediator 12, a transcriptional coactivator, greatly enhances Wnt signaling in the developing embryo. Separate from its role in Wnt signaling, Mediator 12 is required for oxytocin expression.
- Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene
Summary: These data may be the first evidence for a nuclear function of an intermediate filament protein. In cardiac stem cells, desmin interacts with transcription factor complexes influencing Nkx 2.5 transcription.