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VEGF-A

  • RESEARCH ARTICLE
    Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function
    Gareth W. Fearnley, Izma Abdul-Zani, Antony M. Latham, Monica C. Hollstein, John E. Ladbury, Stephen B. Wheatcroft, Adam F. Odell, Sreenivasan Ponnambalam
    Biology Open 2019 8: bio034215 doi: 10.1242/bio.034215 Published 17 May 2019

    Summary: Our study shows that the growth factor VEGF-A stimulates synthesis in endothelial cells of a proto-oncoprotein and protein kinase, Tpl2, and this is required for signal transduction and angiogenesis.

  • RESEARCH ARTICLE
    Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function
    Gina A. Smith, Gareth W. Fearnley, Izma Abdul-Zani, Stephen B. Wheatcroft, Darren C. Tomlinson, Michael A. Harrison, Sreenivasan Ponnambalam
    Biology Open 2017 6: 1404-1415; doi: 10.1242/bio.027896

    Summary: Ubiquitin-mediated modulation of membrane trafficking and turnover of an endothelial receptor tyrosine kinase (VEGFR2) thus regulates proteolysis, receptor activation, signal transduction and downstream cellular responses. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • RESEARCH ARTICLE
    VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
    Gareth W. Fearnley, Gina A. Smith, Izma Abdul-Zani, Nadira Yuldasheva, Nadeem A. Mughal, Shervanthi Homer-Vanniasinkam, Mark T. Kearney, Ian C. Zachary, Darren C. Tomlinson, Michael A. Harrison, Stephen B. Wheatcroft, Sreenivasan Ponnambalam
    Biology Open 2016 5: 571-583; doi: 10.1242/bio.017434

    Summary: We show that vascular endothelial growth factor (VEGF-A) isoforms program differential tyrosine phosphorylation, ubiquitylation, endocytosis and proteolysis of the receptor tyrosine kinase, VEGFR2.

  • RESEARCH ARTICLE
    VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells
    Ayumi Yoshida, Akio Shimizu, Hirotsugu Asano, Tetsuya Kadonosono, Shinae Kizaka Kondoh, Elena Geretti, Akiko Mammoto, Michael Klagsbrun, Misuzu Kurokawa Seo
    Biology Open 2015 4: 1063-1076; doi: 10.1242/bio.010918
  • RESEARCH ARTICLE
    VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration
    Gareth W. Fearnley, Alexander F. Bruns, Stephen B. Wheatcroft, Sreenivasan Ponnambalam
    Biology Open 2015 4: 731-742; doi: 10.1242/bio.201410884

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