VEGF-A
- Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function
Summary: Our study shows that the growth factor VEGF-A stimulates synthesis in endothelial cells of a proto-oncoprotein and protein kinase, Tpl2, and this is required for signal transduction and angiogenesis.
- Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function
Summary: Ubiquitin-mediated modulation of membrane trafficking and turnover of an endothelial receptor tyrosine kinase (VEGFR2) thus regulates proteolysis, receptor activation, signal transduction and downstream cellular responses. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.
- VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
Summary: We show that vascular endothelial growth factor (VEGF-A) isoforms program differential tyrosine phosphorylation, ubiquitylation, endocytosis and proteolysis of the receptor tyrosine kinase, VEGFR2.