Wound healing
- The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts
Summary: Dermal Prrx1-enhancer cells are injury-responsive fibroblasts. Prrx1enh+ cells readily migrate into the wound bed and amplify on average 16-fold beyond their uninjured numbers.
- Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue
Summary: Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue, involving -Akt, SPAK/JNK, and p38 MAPK which in turn are involved in Rac1 activation. Furthermore, these results augment our understanding of the insulin-regulated wound inflammatory response.
- Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury
Summary: Inhibition of miR-29a can promote the proliferation and migration of skin fibroblast cells after thermal injury, and upregulate the production of COL1A2 and VEGF-A to further enhance the collagen synthesis and angiogenesis in skin and help burn wound healing in the later phase.