Zebrafish
- Zebrafish P54 RNA helicases are cytoplasmic granule residents that are required for development and stress resilience
Summary: Stress granules are formed by mRNAs stalled in translation during stress conditions. P54 RNA helicases from zebrafish reside in cytoplasmic granules and are essential for heat-shock resilience.
- Alcohol exposure leads to unrecoverable cardiovascular defects along with edema and motor function changes in developing zebrafish larvae
Summary: Alcohol exposure causes cardiovascular defects along with edema and motor function changes in zebrafish larvae that are unrecoverable in the post-exposure period.
- Cortisol-treated zebrafish embryos develop into pro-inflammatory adults with aberrant immune gene regulation
Summary: Chronically elevated glucocorticoid stress signaling during early zebrafish development has long-term consequences that affect immune gene expression and regulation in adulthood.
- Differences in cardiovascular toxicities associated with cigarette smoking and snuff use revealed using novel zebrafish models
Summary: We analyze common and distinct developmental and cardiovascular toxicities caused by cigarette smoke and snuff, and include a new zebrafish embryo model for studying abdominal aortic aneurysm.
- Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish
Summary: We show that the polyamine spermidine, but not spermine, in addition to more general functions during early development, also specifically regulates colour pattern formation in adult zebrafish.
- Mindbomb 2 is dispensable for embryonic development and Notch signalling in zebrafish
Summary: Mib2 is dispensable for embryonic development and does not have redundant functions with Mib1 in Notch signalling, at least during early development stages in zebrafish.
- The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR
Summary: Here, we tested the zebrafish Kupffer's vesicle (KV) as a model organ to study, through in vivo imaging of KV volume, the stimulation of cystic fibrosis transmembrane conductance regulator (CFTR) in autosomal dominant polycystic kidney disease ADPKD.